Tert-butyl 2,7-diazaspiro(3.5)nonane-7-carboxylate hydrochloride → HCID 58117051, compound

HRID 2066478Notes

Reaction equation

HRID 2066478 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][C@@H]4CCCN4CC3)=[CH:8][C:6]=2[N:7]=1.Cl.[C:28]([O:32][C:33]([N:35]1[CH2:43][CH2:42][C:38]2(CN[CH2:39]2)[CH2:37][CH2:36]1)=[O:34])([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33]([N:35]1[CH2:43][CH2:42][C:38]2([CH2:17][N:12]([CH2:11][C:9]3[S:10][C:5]4[C:4]([N:21]5[CH2:26][CH2:25][O:24][CH2:23][CH2:22]5)=[N:3][C:2]([Cl:1])=[N:7][C:6]=4[CH:8]=3)[CH2:39]2)[CH2:37][CH2:36]1)=[O:34])([CH3:30])([CH3:29])[CH3:31]

Participants

3

Reactant 2

HCID 45489808Tert-butyl 2,7-diazaspiro(3.5)nonane-7-carboxylate hydrochlorideHCID 58117098HCID 58117098, compound

Product 1

HCID 58117051HCID 58117051, compound

Procedure

Prepared according to the method used in the preparation of 2-chloro-6-[(S)-1-(hexahydro-pyrrolo[1,2-d]pyrazin-2-yl)methyl]-4-morpholin-4-yl-thieno[3,2-d]pyrimidine using 2,7-diaza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester hydrochloride in place of (S)-octahydro-pyrrolo[1,2-a]pyrazine. The title compound was obtained as a tan solid (209 mg, 84%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-28accad5109b4e5fbe02cb49a5842838
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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