8-Boc-3,8-diaza-bicyclo(3.2.1)octane → 3-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

HRID 2066480Notes

Reaction equation

HRID 2066480 reaction equation
C(OC(N1CC2C([CH2:11][N:12]([CH2:16][C:17]3[S:25][C:24]4[C:23]([N:26]5[CH2:31][CH2:30][O:29][CH2:28][CH2:27]5)=[N:22][C:21]([Cl:32])=[N:20][C:19]=4[CH:18]=3)[CH2:13]2)C1)=O)(C)(C)C.[C:33]([O:37][C:38]([N:40]1[CH:45]2[CH2:46][CH2:47][CH:41]1CNC2)=[O:39])([CH3:36])([CH3:35])[CH3:34]>>[C:33]([O:37][C:38]([N:40]1[CH:45]2[CH2:46][CH2:47][CH:41]1[CH2:11][N:12]([CH2:16][C:17]1[S:25][C:24]3[C:23]([N:26]4[CH2:27][CH2:28][O:29][CH2:30][CH2:31]4)=[N:22][C:21]([Cl:32])=[N:20][C:19]=3[CH:18]=1)[CH2:13]2)=[O:39])([CH3:36])([CH3:34])[CH3:35]

Participants

3

Reactant 2

HCID 157409088-Boc-3,8-diaza-bicyclo(3.2.1)octaneHCID 581170715-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester

Product 1

HCID 581171213-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

Procedure

Prepared according to the method used in the preparation of 5-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester using 3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester in place of hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester. The title compound was obtained as a tan solid (103 mg, 74%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2822be167c3a410f8671fde45b6e1871
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

Loading…