8-Boc-3,8-diaza-bicyclo(3.2.1)octane → 3-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

HRID 2066481Notes

Reaction equation

HRID 2066481 reaction equation
C(OC(N1CCC2(O[CH2:15][CH2:14][N:13]([CH2:17][C:18]3[S:26][C:25]4[C:24]([N:27]5[CH2:32][CH2:31][O:30][CH2:29][CH2:28]5)=[N:23][C:22]([Cl:33])=[N:21][C:20]=4[CH:19]=3)[CH2:12]2)CC1)=O)(C)(C)C.[C:36]([O:40][C:41]([N:43]1C2[CH2:49][CH2:50][CH:44]1CNC2)=[O:42])([CH3:39])([CH3:38])[CH3:37]>>[C:36]([O:40][C:41]([N:43]1[CH:44]2[CH2:50][CH2:49][CH:15]1[CH2:14][N:13]([CH2:17][C:18]1[S:26][C:25]3[C:24]([N:27]4[CH2:28][CH2:29][O:30][CH2:31][CH2:32]4)=[N:23][C:22]([Cl:33])=[N:21][C:20]=3[CH:19]=1)[CH2:12]2)=[O:42])([CH3:39])([CH3:38])[CH3:37]

Participants

3

Reactant 2

HCID 157409088-Boc-3,8-diaza-bicyclo(3.2.1)octaneHCID 581171354-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1-oxa-4,9-diaza-spiro[5.5]undecane-9-carboxylic acid tert-butyl ester

Product 1

HCID 581171213-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

Procedure

Prepared according to the method used in the preparation of 4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1-oxa-4,9-diaza-spiro[5.5]undecane-9-carboxylic acid tert-butyl ester using 3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester in place of 4-ethoxy-4-methylaminomethyl-piperidine-1-carboxylic acid tert-butyl ester. The title compound was obtained as a cream solid (245 mg, 58%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-79d1bff3932640f6a4f052917ea11714
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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