5-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester → 8-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester

HRID 2066482Notes

Reaction equation

HRID 2066482 reaction equation
C(OC(N1CC2C(C[N:12]([CH2:16][C:17]3[S:25][C:24]4[C:23]([N:26]5[CH2:31][CH2:30][O:29][CH2:28][CH2:27]5)=[N:22][C:21]([Cl:32])=[N:20][C:19]=4[CH:18]=3)[CH2:13]2)C1)=O)(C)(C)C.Cl.[C:34]([O:38][C:39]([N:41]1[CH2:45][CH2:44][C:43]2([CH2:50]CN[CH2:47][CH2:46]2)[CH2:42]1)=[O:40])([CH3:37])([CH3:36])[CH3:35]>>[C:34]([O:38][C:39]([N:41]1[CH2:45][CH2:44][C:43]2([CH2:46][CH2:47][N:12]([CH2:16][C:17]3[S:25][C:24]4[C:23]([N:26]5[CH2:27][CH2:28][O:29][CH2:30][CH2:31]5)=[N:22][C:21]([Cl:32])=[N:20][C:19]=4[CH:18]=3)[CH2:13][CH2:50]2)[CH2:42]1)=[O:40])([CH3:37])([CH3:36])[CH3:35]

Participants

3

Reactant 2

HCID 581170715-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl esterHCID 666620882-Boc-2,8-Diazaspiro[4.5]decane hydrochloride

Product 1

HCID 581171018-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester

Procedure

Prepared according to the method used in the preparation of 5-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester using 2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester hydrochloride in place of hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester. The title compound was obtained as a tan solid (104 mg, 71%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a35bedd07a144694b5d2d8b14742b5be
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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