(8aR)-Octahydropyrrolo(1,2-a)pyrazine → 2-Chloro-6-[(R)-1-(hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)methyl]-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

HRID 2066487Notes

Reaction equation

HRID 2066487 reaction equation
C(OC(N1CC2C([CH2:11][N:12]([CH2:16][C:17]3[S:25][C:24]4[C:23]([N:26]5[CH2:31][CH2:30][O:29][CH2:28][CH2:27]5)=[N:22][C:21]([Cl:32])=[N:20][C:19]=4[CH:18]=3)[CH2:13]2)C1)=O)(C)(C)C.C1NC[CH2:36][N:35]2[CH2:39][CH2:40][CH2:41][C@H:34]12>>[Cl:32][C:21]1[N:22]=[C:23]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[C:24]2[S:25][C:17]([CH2:16][N:12]3[CH2:11][CH2:36][N:35]4[CH2:39][CH2:40][CH2:41][C@@H:34]4[CH2:13]3)=[CH:18][C:19]=2[N:20]=1

Participants

3

Reactant 2

HCID 7004239(8aR)-Octahydropyrrolo(1,2-a)pyrazineHCID 581170715-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester

Product 1

HCID 581170502-Chloro-6-[(R)-1-(hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)methyl]-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Procedure

Prepared according to the method used in the preparation of 5-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester using (R)-octahydro-pyrrolo[1,2-a]pyrazine in place of hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester. The title compound was obtained as white solid (90 mg, 61%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b5adf7bb643a4a9ebab9e97f4d9f4f6a
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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