tert-Butyl 1,8-diazaspiro(4.5)decane-1-carboxylate → 8-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1,8-diaza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester

HRID 2066492Notes

Reaction equation

HRID 2066492 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[C:5]2[S:10][C:9]([CH2:11]N3CCC(NCC4CC4)CC3)=[CH:8][C:6]=2[N:7]=1.[C:29]([O:33][C:34]([N:36]1[C:40]2([CH2:45][CH2:44][NH:43][CH2:42][CH2:41]2)[CH2:39][CH2:38][CH2:37]1)=[O:35])([CH3:32])([CH3:31])[CH3:30]>>[C:29]([O:33][C:34]([N:36]1[C:40]2([CH2:45][CH2:44][N:43]([CH2:11][C:9]3[S:10][C:5]4[C:4]([N:23]5[CH2:28][CH2:27][O:26][CH2:25][CH2:24]5)=[N:3][C:2]([Cl:1])=[N:7][C:6]=4[CH:8]=3)[CH2:42][CH2:41]2)[CH2:39][CH2:38][CH2:37]1)=[O:35])([CH3:32])([CH3:30])[CH3:31]

Participants

3

Reactant 2

HCID 34178602tert-Butyl 1,8-diazaspiro(4.5)decane-1-carboxylateHCID 58117134[1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-cyclopropylmethyl-amine

Product 1

HCID 581170798-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1,8-diaza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester

Procedure

Prepared according to the method used in the preparation of [1-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-cyclopropylmethyl-amine using 1,8-diaza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester in place of cyclopropanemethylamine. The title compound was obtained as a white solid (184 mg, 45%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a993250bf5ca43bebc4e29f6259d00ac
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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