HCID 58117100, compound → HCID 58117080, compound

HRID 2066508Notes

Reaction equation

HRID 2066508 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[S:10][C:9]([CH2:11]N3CC4(CCN(C)CC4)C3)=[CH:8][C:6]=2[N:7]=1.[CH2:28]1[C:31]2([CH2:36][CH2:35][N:34]([C:37](=[O:39])[CH3:38])[CH2:33][CH2:32]2)[CH2:30][NH:29]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[C:5]2[S:10][C:9]([CH2:11][N:29]3[CH2:30][C:31]4([CH2:36][CH2:35][N:34]([C:37](=[O:39])[CH3:38])[CH2:33][CH2:32]4)[CH2:28]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 58117100HCID 58117100, compoundHCID 668703291-(2,7-Diazaspiro[3.5]nonan-7-yl)ethanone

Product 1

HCID 58117080HCID 58117080, compound

Procedure

Prepared according to the method used in the preparation of 2-chloro-6-(7-methyl-2,7-diaza-spiro[3.5]non-2-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine using 1-(2,7-diaza-spiro[3.5]non-7-yl)-ethanone in place of 7-methyl-2,7-diaza-spiro[3.5]nonane. The title compound was obtained as a colourless solid (47 mg, 61%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f5544bf639154e6ba0632faa6c6471ab
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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