3-Fluoroazetidine → HCID 55274302, compound

HRID 2066518Notes

Reaction equation

[F:1][C:2]1(F)[CH2:5][N:4]([CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:3]1.FC1CNC1>>[F:1][CH:2]1[CH2:3][N:4]([CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5]1

Participants

Reactant 2

HCID 36035423-Fluoroazetidine

HCID 596056804-(3,3-Difluoroazetidin-1-yl)piperidine

Product 1

HCID 55274302HCID 55274302, compound

Procedure

Prepared according to the method used in the preparation of 4-(3,3-difluoroazetidin-1-yl)-piperidine using 3-fluoroazetidine in place of 3,3-difluoroazetidine hydrochloride. The title compound was obtained as a colourless oil (180 mg, 39%).

Workup

customPrepared

Sources & evidence

ORD record: ord-e492084670fd42eda07c7467d0160abd
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08293735B2

Reaction notes

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