5,6,7,8-Tetrahydroimidazo(1,2-a)pyrazine → HCID 58117053, compound

HRID 2066523Notes

Reaction equation

HRID 2066523 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][NH:15][C:14](=O)[C:13]3(C)[CH3:19])=[CH:8][C:6]=2[N:7]=1.[N:27]1C=CN2CCNC[C:31]=12>>[Cl:1][C:2]1[N:3]=[C:4]([N:21]2[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]4[CH:14]=[CH:31][N:27]=[C:19]4[CH2:13]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 132470465,6,7,8-Tetrahydroimidazo(1,2-a)pyrazineHCID 86650183HCID 86650183, compound

Product 1

HCID 58117053HCID 58117053, compound

Procedure

Prepared according to the method used in the preparation of 4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-3,3-dimethyl-piperazin-2-one using 5,6,7,8tetrahydro-imidazo[1,2-a]pyrazine in place of 3,3-dimethyl-piperazin-2-one. The title compound was obtained as a pale brown solid (50 mg, 52%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7200f4d7fc2b4adaa8326654552407b7
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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