HCID 55274302, compound → HCID 58117147, compound

HRID 2066524Notes

Reaction equation

HRID 2066524 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[S:10][C:9]([CH2:11]N3CC4(CCN(C)CC4)C3)=[CH:8][C:6]=2[N:7]=1.[F:28][CH:29]1[CH2:32][N:31]([CH:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)[CH2:30]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[C:5]2[S:10][C:9]([CH2:11][N:36]3[CH2:37][CH2:38][CH:33]([N:31]4[CH2:30][CH:29]([F:28])[CH2:32]4)[CH2:34][CH2:35]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 55274302HCID 55274302, compoundHCID 58117100HCID 58117100, compound

Product 1

HCID 58117147HCID 58117147, compound

Procedure

Prepared according to the method used in the preparation of 2-chloro-6-(7-methyl-2,7-diaza-spiro[3.5]non-2-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine using 4-(3-fluoro-azetidin-1-yl)-piperidine in place of 7-methyl-2,7-diaza-spiro[3.5]nonane. The title compound was obtained as a white solid (201 mg, 47%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fdeb63e687fd41b4a5d1db73f294e4e9
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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