1-(Piperidin-4-yl)azetidin-2-one → 1-[1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-azetidin-2-one

HRID 2066527Notes

Reaction equation

HRID 2066527 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[S:10][C:9]([CH2:11]N3CC4(CCN(C)CC4)C3)=[CH:8][C:6]=2[N:7]=1.[NH:28]1[CH2:33][CH2:32][CH:31]([N:34]2[CH2:37][CH2:36][C:35]2=[O:38])[CH2:30][CH2:29]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[C:5]2[S:10][C:9]([CH2:11][N:28]3[CH2:33][CH2:32][CH:31]([N:34]4[CH2:37][CH2:36][C:35]4=[O:38])[CH2:30][CH2:29]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 581170821-(Piperidin-4-yl)azetidin-2-oneHCID 58117100HCID 58117100, compound

Product 1

HCID 581171101-[1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-azetidin-2-one

Procedure

Prepared according to the method used in the preparation of 2-chloro-6-(7-methyl-2,7-diaza-spiro[3.5]non-2-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine using 1-piperidin-4-yl-azetidin-2-one in place of 7-methyl-2,7-diaza-spiro[3.5]nonane. The title compound was obtained as a pale yellow solid (205 mg, 81%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7d3dab3abc0e44b5b948210ffa31ce09
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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