2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde → HCID 58117044, compound

HRID 2066549Notes

Reaction equation

HRID 2066549 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH:11]=O)=[CH:8][C:6]=2[N:7]=1.[O:19]1[CH2:23][CH2:22][CH:21]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:20]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH2:11][N:27]3[CH2:26][CH2:25][N:24]([CH:21]4[CH2:22][CH2:23][O:19][CH2:20]4)[CH2:29][CH2:28]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehydeHCID 532499461147422-71-6

Product 1

HCID 58117044HCID 58117044, compoundYield 60%

Procedure

Prepared from 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde and 1-(tetrahydro-furan-3-yl-piperazine under reductive amination conditions described in Reference Example 39, to give after silica chromatography, the title compound as a white solid (217 mg, 60%).

Workup

  1. customto give after silica chromatography

Sources & evidence

ORD record
ord-a5c0fccaffd74155a29cfd6fc1bc5e8b
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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