Trifluoroacetic acid → 2-Chloro-6-(hexahydro-pyrrolo[3,4-c]pyrrol-2-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Participants

Reaction Steps

To a stirred solution of 5-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester (390 mg; 0.81 mmol) in CH2Cl2 (4 mL) was added TFA (6 mL). The reaction mixture was stirred at RT for 4 h upon which time volatiles were removed in vacuo. Purification by SCX-2 gave the title compound as an off-white solid (273 mg; 89%).

Provenance & Evidence