Trifluoroacetic acid methylene chloride → HCID 46240000, compound

HRID 2066558Notes

Reaction equation

HRID 2066558 reaction equation
C(OC([N:8]1[CH:16]2[CH:11]([CH2:12][N:13]([CH2:17][C:18]3[S:26][C:25]4[C:24]([N:27]5[CH2:32][CH2:31][O:30][CH2:29][CH2:28]5)=[N:23][C:22]([C:33]5[CH:41]=[C:40]([F:42])[CH:39]=[C:38]6[C:34]=5[CH:35]=[CH:36][NH:37]6)=[N:21][C:20]=4[CH:19]=3)[CH2:14][CH2:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[F:42][C:40]1[CH:39]=[C:38]2[C:34]([CH:35]=[CH:36][NH:37]2)=[C:33]([C:22]2[N:23]=[C:24]([N:27]3[CH2:28][CH2:29][O:30][CH2:31][CH2:32]3)[C:25]3[S:26][C:18]([CH2:17][N:13]4[CH2:14][CH2:15][CH:16]5[NH:8][CH2:9][CH2:10][CH:11]5[CH2:12]4)=[CH:19][C:20]=3[N:21]=2)[CH:41]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 58117089HCID 58117089, compound

Product 1

HCID 46240000HCID 46240000, compound

Procedure

Prepared by BOC-deprotection of 5-[2-(6-fluoro-1H-indol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl]-octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester using TFA:DCM (1:6). The title compound was obtained as a white solid (8.3 mg, 7%).

Sources & evidence

ORD record
ord-fc8eeaaf01cd4b40b26ee1eaecff8901
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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