HCID 66997518, compound → HCID 66997561, compound

HRID 2066572Notes

Reaction equation

HRID 2066572 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[F:27])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:22])[CH:10]=[N+:11]([O-])[C:12]=2[C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:7]1=[O:23]>C(OC(=O)C)(=O)C>[C:16]([O:18][C:10]1[N:11]=[C:12]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:13]2[CH2:14][CH2:15][N:6]([CH2:5][C:4]3[CH:24]=[CH:25][C:26]([F:27])=[C:2]([Cl:1])[CH:3]=3)[C:7](=[O:23])[C:8]=2[C:9]=1[O:22][C:9](=[O:22])[CH3:8])(=[O:17])[CH3:12]

Participants

3

Reactant 1

HCID 66997518HCID 66997518, compound

Product 1

HCID 66997561HCID 66997561, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of ethyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate 2-oxide (23 g, 58 mmol) in acetic anhydride (400 mL) was heated under nitrogen at 100° C. for one hour. The product mixture was concentrated under vacuum to the title bisacetate and was used in the following step without further purification.

Workup

  1. concentrationThe product mixture was concentrated under vacuum to the title bisacetate
  2. customwas used in the following step without further purification

Sources & evidence

ORD record
ord-eed338bb5d524bb4acb083bbedb29e6d
Source dataset
uspto-grants-2012_10
Patent number
US08293731B2

Reaction notes

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