Acetone → 2-Chloro-5-(4-fluoro-benzyloxy)-quinoline

HRID 206665Notes

Reaction equation

HRID 206665 reaction equation
[C:13](=[O:14])([O-:15])[O-:16].[CH3:28][C:29](=[O:30])[CH3:31].[F:19][c:20]1[cH:21][cH:22][c:23]([CH2:24][Br:25])[cH:26][cH:27]1.[K+:17].[K+:18].[OH:1][c:2]1[c:3]2[cH:4][cH:5][c:6]([Cl:12])[n:7][c:8]2[cH:9][cH:10][cH:11]1>>[O:1]([c:2]1[c:3]2[cH:4][cH:5][c:6]([Cl:12])[n:7][c:8]2[cH:9][cH:10][cH:11]1)[CH2:24][c:23]1[cH:22][cH:21][c:20]([F:19])[cH:27][cH:26]1

Participants

6

Reactant 5

HCID 180AcetoneHCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 680214-Fluorobenzyl bromideHCID 1354422212-chloroquinolin-5-ol

Product 1

HCID 866194962-Chloro-5-(4-fluoro-benzyloxy)-quinoline

Sources & evidence

ORD record
ord-bf39abcb4a1342b69a78bb8b4a0ce683
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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