HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-(3-nitrobenzyl)piperazine → 3-[(4-Methylpiperazin-1-yl)methyl]aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-(3-nitrobenzyl)piperazine | HCID 1377109 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-[(4-Methylpiperazin-1-yl)methyl]aniline | HCID 6484186 | — |
Reaction Steps
A suspension of 1-methyl-4-(3-nitro-benzyl)-piperazine (6.9 g, 29.14 mmol) and Raney Nickel (2 g) in MeOH (150 mL) is stirred for 5 h at RT, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of celite and concentrated to afford the title compound as a yellow solid: ESI-MS: 206.1 [MH]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293746B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-7e281c10ae5240cca5ad3cb996e8124d |
| Source note | uspto-grants-2012_10 |