1-Isopropyl-4-(4-nitrophenyl)piperazine → 4-[4-(Propan-2-yl)piperazin-1-yl]aniline

Participants

Reaction Steps

A suspension of 1-isopropyl-4-(4-nitro-phenyl)-piperazine (5.18 g, 20.80 mmol) and 5% palladium on carbon (0.5 g) in MeOH (100 mL) is stirred for 2.7 h at RT, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of celite and concentrated to afford the title compound as a violet solid: ESI-MS: 220.1 [MH]+; tR=0.95 min (system 1).

Provenance & Evidence