HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(2-Fluoro-4-nitrophenoxy)ethyl]pyrrolidine → 3-Fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(2-Fluoro-4-nitrophenoxy)ethyl]pyrrolidine | HCID 25248766 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)aniline | HCID 19627246 | — |
Reaction Steps
A suspension of 1-[2-(2-fluoro-4-nitro-phenoxy)-ethyl]-pyrrolidine (1.25 g, 4.92 mmol) and 10% palladium on carbon (0.2 g) in EtOH (20 mL) is stirred for 1 h at RT, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of celite and concentrated to afford the title compound as a brown oil: ESI-MS: 225.1 [MH]+; tR=0.80 min (system 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293746B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-bf8fe2607ae241b6a1109caa7acec8cf |
| Source note | uspto-grants-2012_10 |