HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 3,3,3-Trifluoro-2,2-dimethylpropanoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3,3,3-Trifluoro-2,2-dimethylpropanoic acid | HCID 19867367 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3,3,3-Trifluoro-2,2-dimethylpropanoyl chloride | HCID 57417092 | — |
Reaction Steps
DMF (3 drops) was added to a solution of 3,3,3-trifluoro-2,2-dimethyl-propionic acid [889940-13-0] (179 mmol) in CH2Cl2 (160 mL) at rt. Slowly added a solution of oxalyl chloride (197 mmol) in CH2Cl2 (20 mL). After stirring for 14 h, the reaction mixture was carefully evaporated (500 mbar, 33° C.) to afford the title compound (volatile!) as a yellow solution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293753B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-573b7e3b52ca430b9d9bbb4f48a05131 |
| Source note | uspto-grants-2012_10 |