HCID 58092768, compound → HCID 58092707, compound

HRID 2066799Notes

Reaction equation

HRID 2066799 reaction equation
[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][N:6]([C@H](C2C=CC=CC=2)C)[C@@H:5]1[C:17]([NH2:19])=[O:18]>[Pd].O>[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][NH:6][C@@H:5]1[C:17]([NH2:19])=[O:18]

Participants

4

Reactant 1

HCID 58092768HCID 58092768, compound

Product 1

HCID 58092707HCID 58092707, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 1.8 but (2S,3R)-3-methoxymethyl-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid amide (Step 14.2) was used instead of (2S,3R)-3-methyl-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid amide. Moreover, 10% Pd on charcoal, wet with 50% H2O (Aldrich 330108) was used instead of the dry catalyst.

Sources & evidence

ORD record
ord-fa2648b7ce404e488acf16098543cb99
Source dataset
uspto-grants-2012_10
Patent number
US08293753B2

Reaction notes

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