Sodium Azide → HCID 59409882, compound

Participants

Reaction Steps

A mixture of (5S)-5-(chloromethyl)-3-(5-chloropyridin-2-yl)-1,3-oxazolidin-2-one (2.44 g, INTERMEDIATE 6) and sodium azide (1.28 g) was heated to 100° C. in 80 ml of dimethylformamide for 15 h. The mixture was then diluted with 500 ml of water and extracted with 500 ml of ethyl acetate (3×). The combined organic layers were washed with water (250 ml) and brine (250 ml). They were then dried over sodium sulfate and concentrated in vacuo to provide 2.31 g (92%) of the title compound in >95% purity via LC/MS. Mass spectrum (ESI) 254.1 (M+1).

Provenance & Evidence