Benzylamine → HCID 6931954, compound

HRID 2066812Notes

Reaction equation

HRID 2066812 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:9]([C@H:11]1[O:13][CH2:12]1)[Cl:10]>>[CH2:1]([NH:8][CH2:12][C@H:11]([OH:13])[CH2:9][Cl:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 149428(+)-Epichlorohydrin

Product 1

HCID 6931954HCID 6931954, compoundYield 50.1%

Procedure

A scintillation vial was charged with benzylamine (1 g, 10 mmol), anhydrous petroleum ether (10 ml) and a stir bar. To this was added (S)-(+)-epichlorohydrin (0.925 g, 10 mmol) dropwise over a period of 20 min and the mixture was allowed to stir at room temperature. After 15 h, the white crystals precipitated from solution. These were collected by suction filtration, rinsed with cold petroleum ether (10 ml) and dried under vacuum to provide the title compound (1.0 g, 50%). Mass spectrum (ESI) 200.1 (M+1).

Workup

  1. customthe white crystals precipitated from solution
  2. filtrationThese were collected by suction filtration
  3. washrinsed with cold petroleum ether (10 ml)
  4. customdried under vacuum

Sources & evidence

ORD record
ord-49044c0758c443558a040f010852edb7
Source dataset
uspto-grants-2012_10
Patent number
US08293721B2

Reaction notes

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