HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 86655013, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3,5,6-Trichloro-pyrazine-2-carboxylic acid methyl ester | HCID 15258205 | — |
| Reactant | Isopropyl 4-(Piperidin-4-ylideneaminooxy)piperidine-1-carboxylate | HCID 57461147 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | HCID 86655013 | HCID 86655013 | — |
Reaction Steps
2d (99 mg, 0.35 mmol), 56a (92 mg, 0.35 mmol) and diisopropylethylamine (0.1 mL, 0.6 mmol) were combined in 0.5 mL of DMSO and stirred at room temperature for 18 h. The mixture was diluted with aqueous NaHCO3 (5 mL) and extracted with EtOAc (5 mL). The organic layer was concentrated under vacuum to afford the crude 56b. 20 mg of this crude material was purified by preparative HPLC to afford 56b: LC-MS 488.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293729B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-d69272d16ad240e8a6b48eb2e1805719 |
| Source note | uspto-grants-2012_10 |