HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Thiosulfate → 4-[1-(4,5-Diamino-2-fluoro-phenyl)-piperidin-4-ylideneaminooxy]-piperidine-1-carboxylic acid isopropyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Thiosulfate | HCID 24477 | — |
| Reactant | 4-[1-(5-Amino-2-fluoro-4-nitro-phenyl)-piperidin-4-ylideneaminooxy]-piperidine-1-carboxylic acid isopropyl ester | HCID 86655019 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 4-[1-(4,5-Diamino-2-fluoro-phenyl)-piperidin-4-ylideneaminooxy]-piperidine-1-carboxylic acid isopropyl ester | HCID 86655020 | — |
Reaction Steps
60a obtained in the previous step was dissolved in acetonitrile (4 mL) and treated with Na2S2O3 (0.42 g) in 1N NaOH (4 mL). After 20 h, the mixture was poured in water and extracted with EtOAc twice. The combined extracts were dried and concentrated to afford the crude 60b.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293729B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-c566be363f8d4be885d5b9aa8d73db2d |
| Source note | uspto-grants-2012_10 |