HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2066887Generated: November 3, 2026
Dimethyl Sulfoxide → HCID 58333635, compound
https://huagongshe.com/reaction/2066887
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | 2-Fluoropyridine | HCID 9746 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(2-Fluoro-4-methanesulfonyl-phenyl)-piperidin-4-one O-piperidin-4-yl-oxime | HCID 86655022 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 58333635 | HCID 58333635 | — |
Reaction Steps
30 mg of 63a (0.08 mmol), diisopropylethylamine (75 μL, 0.43 mmol), DMSO (0.3 mL) and 2-fluoropyridine (11.7 mg, 0.12 mmol) were combined and heated to 120° C. overnight. The mixture was diluted with methanol and purified on preparative HPLC to give 63-1: LC-MS 447.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08293729B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-6a750b79f7c04614a0a72fb0651e3e9c |
|---|
| Source note | uspto-grants-2012_10 |
|---|
