HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 58333576, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Methyl-1H-pyrrole-2-carbaldehyde | HCID 14504 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1-(2-Fluoro-4-methanesulfonyl-phenyl)-piperidin-4-one O-piperidin-4-yl-oxime | HCID 86655022 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58333576 | HCID 58333576 | — |
Reaction Steps
To 63a (24 mg, 0.065 mmol) in 1 mL of DCM, was added 1-methyl-1H-pyrrole-2-carbaldehyde (10.6 g, 0.098 mmol), triethylamine (27 μL, 0.19 mmol) and sodium triacetoxyborohydride (27.6 mg, 0.13 mmol). The mixture was stirred overnight at room temperature, concentrated and purified on preparative HPLC to give 66-1: LC-MS 463.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293729B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-c87e000c38be41bc9b806b2e3bd7d6ae |
| Source note | uspto-grants-2012_10 |