HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → (2,6-Dichloropyridin-3-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 2,6-Dichloropyridine-3-carbaldehyde | HCID 12259383 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2,6-Dichloropyridin-3-yl)methanol | HCID 12259932 | — |
Reaction Steps
Sodium borohydride (125 mg, 4.49 mmol) was added to 2,6-dichloro-pyridine-3-carbaldehyde (0.62 g, 3.5 mmol) in 20 mL of methanol at 0° C. After 30 minutes, the mixture was quenched with NaHCO3 (20 mL) and water (20 mL) and extracted with EtOAc (2×20 mL). The combined extracts were dried and concentrated under vacuum to afford 72a: LC-MS178.0 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293729B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-4948468dacd54fb58a4772fbfceffa1e |
| Source note | uspto-grants-2012_10 |