HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 58333439, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 1-(2-Fluoro-4-methanesulfonyl-phenyl)-piperidin-4-one O-piperidin-4-yl-oxime | HCID 86655022 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58333439 | HCID 58333439 | — |
Reaction Steps
A solution of 63a (135 mg, 0.35 mmol) and pyridine (85 μL, 1.05 mmol) in DCM (5 mL) was added to a solution of triphosgene (37 mg, 0.123 mmol) in DCM (6 mL) and stirred at r.t. for 1 h. 0.5 mL of this solution was transferred to a vial, piperidine (0.01 mL) was added and the mixture stirred at r.t. for 2 h, diluted with methanol and purified by HPLC yielding 73-1. LC-MS 481.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293729B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-3c9c5e81cf3c4cae971d8a0323fa0458 |
| Source note | uspto-grants-2012_10 |