HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Chloride → HCID 69077541, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Chloride | HCID 7503 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | ethyl 2,5-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate | HCID 336248 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 69077541 | HCID 69077541 | 45% |
Reaction Steps
A mixture of 252 mg of ethyl 2,5-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate, 138 mg of potassium carbonate, 15 mL of acetonitrile and 1 mL of benzyl chloride was heated under reflux overnight. After condensing the reaction mixture under reduced pressure, the residue was purified on silica gel column chromatography (chloroform:methanol=100:1) to provide 153 mg (45%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293754B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-a814d61bb4f34ac1acbff88eaea2098b |
| Source note | uspto-grants-2012_10 |