Methanol → HCID 178499180, compound

Participants

Reaction Steps

Thionyl chloride (2.90 ml, 39.8 mmol) is slowly added to a mixture of 4-nitro-3-pyrazolecarboxylic acid (5.68 g, 36.2 mmol) in methanol (100 ml) at ambient temperature and the mixture is stirred for 48 hours. The mixture is reduced in vacuo and dried through azeotrope with toluene to afford the 4-nitro-1H-pyrazole-3-carboxylic acid methyl ester.

Provenance & Evidence