HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 4-(2-(4-Aminonaphthalen-1-yloxy)ethyl)pyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 4-(2-(4-Nitronaphthalen-1-yloxy)ethyl)pyridin-3-amine | HCID 58416778 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(2-(4-Aminonaphthalen-1-yloxy)ethyl)pyridin-3-amine | HCID 58416779 | 96.8% |
Reaction Steps
A solution of 4-(2-(4-nitronaphthalen-1-yloxy)ethyl)pyridin-3-amine (17) (700 mg, 2.263 mmol) in a mixture of MeOH (50 mL), EtOAc (25 mL), and DCM (25 mL) was passed through a Thales H-cube (10% Pt/C 30 mm, 1.0 mL·min−1, at 40° C., full hydrogen mode). The solvent was removed in vacuo to give 4-(2-(4-aminonaphthalen-1-yloxy)ethyl)pyridin-3-amine (18) as a brown solid (612 mg, 92%). m/z 280 (M+H)+ (ES+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293748B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-a16100b1f9b947d2a3b44ea99103a689 |
| Source note | uspto-grants-2012_10 |