HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetic Acid → 2-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetic Acid | HCID 6227 | — |
| Reactant | 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one | HCID 24849570 | — |
| Product | 2-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)acetic acid | HCID 24849714 | — |
Reaction Steps
The title compound was prepared from 2-bromoacetic acid and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedure outlined in Example 25. 1H NMR (400 MHz, DMSO-d6): δ 12.90 (br, 1H), 9.56 (br s, 1H), 8.83 (s, 2H), 7.97 (d, 1H), 7.23 (d, 1H), 4.66 (s, 1H), 4.65 (s, 2H), 3.94 (s, 3H); MS (ESI): 410.8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745646B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-f0f9042eaab34af7a44e0f7e057a5f6c |
| Source note | uspto-grants-2010_06 |