Hydrazine → HCID 86662097, compound

HRID 2067103Notes

Reaction equation

HRID 2067103 reaction equation
[Br:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[C:14]3[N:15]=[CH:16][CH:17]=[CH:18][C:13]=3[C:12](=S)[C:11]([C:20]([O:22]CC)=O)=[N:10]2)=[CH:4][CH:3]=1.[NH2:25][NH2:26]>C(O)C>[Br:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[C:14]3[N:15]=[CH:16][CH:17]=[CH:18][C:13]=3[C:12]3=[N:25][NH:26][C:20](=[O:22])[C:11]3=[N:10]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 86662095HCID 86662095, compound

Product 1

HCID 86662097HCID 86662097, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 1-[(6-bromopyridin-3-yl)methyl]-4-thioxo-1,4-dihydropyrido[2,3-c]pyridazine-3-carboxylate (120 mg, 0.296 mmol) was suspended in ethanol (15 mL), treated with hydrazine (1.00 mL, 31.9 mmol, 107 equiv) and placed into an oil bath preheated to 80° C. for 1 hour. The mixture was cooled to ambient temperature and concentrated in vacuo, providing the titled compound.

Workup

  1. customplaced into an oil bath
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-25e457b760a248c3a8cde09344783697
Source dataset
uspto-grants-2012_10
Patent number
US08293744B2

Reaction notes

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