Lawesson's reagent → HCID 86662105, compound

Participants

Reaction Steps

Ethyl 4-oxo-1-{[4-(1H-pyrazol-1-yl)phenyl]methyl}-1,4-dihydrothieno[3,2-c]pyridazine-3-carboxylate (37 mg, 0.097 mmol) suspended in dioxane (5 mL) and toluene (5 mL), placed into an oil bath preheated at 110° C. and treated with Lawesson's Reagent (39 mg, 0.097 mmol, 1 equiv) portionwise over 10 minutes. The mixture was heated for an additional 30 minutes, cooled to ambient temperature and concentrated in vacuo. The residue was purified by silica gel gradient chromatography (100:0 to 25:75; hexanes:ethyl acetate), providing the titled compound as a brown oil.

Provenance & Evidence