Hydrazine → HCID 66745424, compound

HRID 2067125Notes

Reaction equation

HRID 2067125 reaction equation
S=[C:2]1[C:7]([C:8](OCC)=[O:9])=[N:6][N:5]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH:24]=[CH:23][CH:22]=[N:21]3)=[CH:16][CH:15]=2)[C:4]2[CH:25]=[CH:26][S:27][C:3]1=2.[NH2:28][NH2:29]>C(O)C>[N:20]1([C:17]2[CH:18]=[CH:19][C:14]([CH2:13][N:5]3[C:4]4[CH:25]=[CH:26][S:27][C:3]=4[C:2]4=[N:28][NH:29][C:8](=[O:9])[C:7]4=[N:6]3)=[CH:15][CH:16]=2)[CH:24]=[CH:23][CH:22]=[N:21]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 86662105HCID 86662105, compound

Product 1

HCID 66745424HCID 66745424, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 4-thioxo-1-{[4-(1H-pyrazol-1-yl)phenyl]methyl}-1,4-dihydrothieno[3,2-c]pyridazine-3-carboxylate (23 mg, 0.058 mmol) and hydrazine (1.0 mL, 31 mmol, 550 equiv) were combined in absolute ethanol (7 mL) and placed into an oil bath preheated to 85° C. for 2 hours. The mixture was cooled to ambient temperature and concentrated in vacuo, providing the titled compound.

Workup

  1. customplaced into an oil bath
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-af34916a19fa4ee5ba5533a14ec4ff81
Source dataset
uspto-grants-2012_10
Patent number
US08293744B2

Reaction notes

Loading…