(4-{7-[Bis-(2-trimethylsilanyl-ethoxymethyl)-amino]-6-bromo-3-quinolin-3-yl-pyrazolo[1,5-a]pyrimidin-5-yl}-cyclohexyl)-acetic acid ethyl ester → 2-[4-[7-[Bis(2-trimethylsilylethoxymethyl)amino]-6-bromo-3-quinolin-3-ylpyrazolo[1,5-a]pyrimidin-5-yl]cyclohexyl]acetonitrile
Reaction equation
[CH3:1][Si:2]([CH2:3][CH2:4][O:5][CH2:6][N:7]([c:8]1[c:9]([Br:39])[c:10]([CH:27]2[CH2:28][CH2:29][CH:30]([CH2:33][C:34]([O:35][CH2:36][CH3:37])=[O:38])[CH2:31][CH2:32]2)[n:11][c:12]2[n:13]1[n:14][cH:15][c:16]2-[c:17]1[cH:18][n:19][c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[cH:26]1)[CH2:40][O:41][CH2:42][CH2:43][Si:44]([CH3:45])([CH3:46])[CH3:47])([CH3:48])[CH3:49].[CH3:50][Si:51]([CH3:52])([CH3:53])[CH2:54][CH2:55][O:57][CH2:58][N:56]([CH2:59][O:60][CH2:61][CH2:62][Si:63]([CH3:64])([CH3:65])[CH3:66])[c:67]1[n:68]2[n:69][cH:70][c:71](-[c:72]3[cH:73][n:74][c:75]4[c:76]([cH:77]3)[cH:78][cH:79][cH:80][cH:81]4)[c:82]2[n:83][c:84]([CH:85]2[CH2:86][CH2:87][CH:88]([CH2:89][C:90]#[N:91])[CH2:92][CH2:93]2)[cH:94]1.[CH3:95][Si:96]([CH3:97])([CH3:98])[CH2:99][CH2:100][O:101][CH2:102][N:103]([CH2:104][O:105][CH2:106][CH2:107][Si:108]([CH3:109])([CH3:110])[CH3:111])[c:112]1[n:113]2[n:114][cH:115][c:116](-[c:117]3[cH:118][n:119][c:120]4[c:121]([cH:122]3)[cH:123][cH:124][cH:125][cH:126]4)[c:127]2[n:128][c:129]([CH:130]2[CH2:131][CH2:132][CH:133]([CH2:134][C:135]([O:136][CH2:137][CH3:138])=[O:139])[CH2:140][CH2:141]2)[cH:142]1>>[CH3:1][Si:2]([CH2:3][CH2:4][O:5][CH2:6][N:7]([c:8]1[c:9]([Br:39])[c:10]([CH:27]2[CH2:28][CH2:29][CH:30]([CH2:33][C:34]#[N:56])[CH2:31][CH2:32]2)[n:11][c:12]2[n:13]1[n:14][cH:15][c:16]2-[c:17]1[cH:18][n:19][c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[cH:26]1)[CH2:40][O:41][CH2:42][CH2:43][Si:44]([CH3:45])([CH3:46])[CH3:47])([CH3:48])[CH3:49]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-37afa63b45bd4bf382d1c90b47607c3d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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