HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Hexynoic acid → 6-[3-(2-Hydroxy-1-methyl-ethylcarbamoyl)phenyl]-hex-5-ynoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Hexynoic acid | HCID 143036 | — |
| Reactant | N-(2-hydroxy-1-methyl-ethyl)-3-iodobenzamide | HCID 23730076 | — |
| Product | 6-[3-(2-Hydroxy-1-methyl-ethylcarbamoyl)phenyl]-hex-5-ynoic acid | HCID 11358215 | 99% |
Reaction Steps
The iodobenzamide (1) (2.00 g, 6.5 mmol) was coupled with 5-hexynoic acid using method B giving product (4) (1.87 g, 6.42 mmol; 99% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293796B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-884796ff2b914ee6bbd641125db512bc |
| Source note | uspto-grants-2012_10 |