HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 11449562, compound → HCID 72806257, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 11449562 | HCID 11449562 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | HCID 72806257 | HCID 72806257 | 40% |
Reaction Steps
Hydrogenation of 3-(5-dimethylcarbamoyl-pent-1-ynyl)-N-(2-fluoro-ethyl)benzamide (26) (0.040 g, 0.13 mmol) using BER/Ni catalyst gave 40% 28, and 55% of starting material. The mixture was separated by reverse-phase HPLC chromatography (30% acetonitrile/70% water 20 min isocratic program) to give 3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-fluoro-ethyl)-benzamide 28 (5 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293796B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-d48104cf7a1b4be6be406a77acba69d5 |
| Source note | uspto-grants-2012_10 |