Diisopropylethylamine → HCID 57725407, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-chloro-6-methoxybenzo[d]thiazole (2.0 g, 10 mmol) in 10 mL of NMP was added (S)-1-cyclohexylethanamine (2.3 g, 18 mmol) and DIPEA (3.5 mL, mmol). The reaction solution was stirred at 110° C. for 96 hours. The reaction was diluted with EtOAc (170 mL) and washed with saturated NaHCO3 (60 mL), 5% NaHCO3 solution (60 mL), water (60 mL), saturated NaCl (60 mL), dried over sodium sulfate, filtered and concentrated in vacuo to give (S)—N-(1-cyclohexylethyl)-6-methoxybenzo[d]thiazol-2-amine as crude solid (3.39 grams). ES/MS m/z 291.1 (MH+).

Provenance & Evidence