Cesium carbonate → HCID 25119209, compound

Participants

Reaction Steps

To a reaction mixture of 2-((1R,2R)-2-hydroxycyclohexylamino)benzo[d]thiazol-6-ol (15.1 mg, 0.057 mmol; see Example 3 above) in 0.4 mL of NMP was added cesium carbonate (47 mg, 0.143 mmol) and stirred for 1-3 min at room temperature. To this mixture was added 4-chloroquinazoline (18.8 mg, 0.114 mmol). The reaction mixture was stirred at room temperature for 5 hours or until done by LC. The crude reaction mixture was filtered, purified by preparative HPLC, freebased, concentrated under reduced pressure and lyophilized to give the title compound (7.4 mg) as a solid. ES/MS m/z 393.2 (MHS, Rt=2.10 min.

Provenance & Evidence