Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To a solid tert-butyl 4-(5-(2-((1R,2R)-2-hydroxycyclohexylamino)benzo[d]thiazol-6-yloxy)pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate (7.2 mg, 0.0138 mmol, see Example 25 above) was added 4M HCl in Dioxane (1 mL, 4.0 mmol). The reaction mixture was stirred at room temperature for 1 hour. The crude reaction mixture was concentrated to a solid and lyophilized to give title compound as HCl salt (4.8 mg). ES/MS m/z 423.2 (MH+), Rt=1.72 min.

Provenance & Evidence