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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2067195Generated: November 3, 2026

[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanone → HCID 11548643, compound

https://huagongshe.com/reaction/2067195

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanoneHCID 11706669—
ReactantHCID 58677657HCID 58677657—
Reactant2-(3-Azido-propoxy)-tetrahydro-pyranHCID 86605521—
ProductHCID 11548643HCID 11548643—

Reaction Steps

The reaction was carried out similarly as described in the preparation of compound 101, using compound 407 (0.44 mmol) and compound 409 (0.44 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 10:90 to 50:50 as the eluent to afford the title compound as colourless foam.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08293772B2
Source datasetuspto-grants-2012_10
ORD IDord-8c38657d7bf04ee2a374b4ba6d07d021
Source noteuspto-grants-2012_10