HuagongsheHuagongshe Chemistry Print Report · For research reference only
[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanone → HCID 11548643, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanone | HCID 11706669 | — |
| Reactant | HCID 58677657 | HCID 58677657 | — |
| Reactant | 2-(3-Azido-propoxy)-tetrahydro-pyran | HCID 86605521 | — |
| Product | HCID 11548643 | HCID 11548643 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 101, using compound 407 (0.44 mmol) and compound 409 (0.44 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 10:90 to 50:50 as the eluent to afford the title compound as colourless foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-8c38657d7bf04ee2a374b4ba6d07d021 |
| Source note | uspto-grants-2012_10 |