2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-toluenesulfonate → 4-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane

Participants

Reaction Steps

The reaction was carried out similarly as described in the preparation of compound 408, using toluene-4-sulfonic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester (37.8 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 0:100 to 20:80 as the eluent to afford the title compound as colourless foam.

Provenance & Evidence