HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane → HCID 11497523, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane | HCID 11535602 | — |
| Reactant | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanone | HCID 11706669 | — |
| Reactant | HCID 58677657 | HCID 58677657 | — |
| Product | HCID 11497523 | HCID 11497523 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 101, using compound 407 (1.37 mmol) and compound 410 (1.62 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 20:80 to 35:65 as the eluent to afford the title compound as yellow foam. 13C NMR (DMSO-d6) δ 194.9, 158.7 (dd), 155.7 (dd), 149.4, 145.2, 139.8, 135.9, 133.7, 133.7, 131.7, 128.2, 127.1, 126.5, 126.5 (dd), 125.0, 124.2 (dd), 122.3, 114.8, 111.9 (dd), 111.8, 109.0, 105.0 (dd), 73.7, 65.8, 52.0, 26.4, 25.1, 19.4
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-5cda3fb023a4410ba22c304debc62a44 |
| Source note | uspto-grants-2012_10 |