HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-azido-acetamide → HCID 11533128, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-azido-acetamide | HCID 3246223 | — |
| Reactant | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanone | HCID 11706669 | — |
| Reactant | HCID 58677657 | HCID 58677657 | — |
| Product | HCID 11533128 | HCID 11533128 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 101, using compound 407 (0.44 mmol) and compound 411. The crude product was purified by continuous gradient flash chromatography using MeOH/DCM 0:100 to 10:90 as the eluent to afford the title compound as yellow solid. 13C NMR (DMSO-d6) δ 194.9, 167.1, 158.7 (dd), 155.7 (dd), 149.3, 145.2, 139.8, 135.9, 133.7, 133.7, 131.7, 128.2, 127.1, 126.6, 126.4 (dd), 125.0, 124.2 (dd), 123.0, 114.9, 112.0 (dd), 111.8, 105.0 (dd), 51.5, 19.4
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-03198019a8a14c5ca1aea64077d5f3cf |
| Source note | uspto-grants-2012_10 |