(2-Chloro-4-o-tolylamino-phenyl)-(2-methyl-5-nitro-phenyl)-methanone → (5-Amino-2-methyl-phenyl)-(2-chloro-4-o-tolylamino-phenyl)-methanone

HRID 2067211Notes

Reaction equation

HRID 2067211 reaction equation
NC1C=CC(C)=C(C(C2C=CC(NC3C=CC(C(F)(F)F)=CC=3)=CC=2Cl)=O)C=1.[Cl:29][C:30]1[CH:35]=[C:34]([NH:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=2[CH3:43])[CH:33]=[CH:32][C:31]=1[C:44]([C:46]1[CH:51]=[C:50]([N+:52]([O-])=O)[CH:49]=[CH:48][C:47]=1[CH3:55])=[O:45]>>[NH2:52][C:50]1[CH:49]=[CH:48][C:47]([CH3:55])=[C:46]([C:44]([C:31]2[CH:32]=[CH:33][C:34]([NH:36][C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=3[CH3:43])=[CH:35][C:30]=2[Cl:29])=[O:45])[CH:51]=1

Participants

3

Reactant 2

HCID 68418373(2-Chloro-4-o-tolylamino-phenyl)-(2-methyl-5-nitro-phenyl)-methanoneHCID 68419668(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone

Product 1

HCID 68417734(5-Amino-2-methyl-phenyl)-(2-chloro-4-o-tolylamino-phenyl)-methanone

Procedure

The reaction was carried out similarly as described in the preparation of compound 415, using compound 417 (0.39 mmol). The crude product was used without any further purification.

Workup

  1. customThe crude product was used without any further purification

Sources & evidence

ORD record
ord-cfe0f526b9254355a236ce3800219f53
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

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