HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, 2-chloro-4-fluoro- → [2-Chloro-4-(2-chloro-4-fluoro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, 2-chloro-4-fluoro- | HCID 75013 | — |
| Reactant | (4-Bromo-2-chloro-phenyl)-(2-methyl-5-nitro-phenyl)-methanone | HCID 11494123 | — |
| Reactant | [2-Chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone | HCID 68419760 | — |
| Product | [2-Chloro-4-(2-chloro-4-fluoro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone | HCID 68421804 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 414, using compound 402 (0.28 mmol) and 2-chloro-4-fluoroaniline (0.28 mmol). The crude product was purified by continuous gradient flash chromatography using MeOH/EtOAc 0:100 to 25:75 as the eluent to afford the title compound as yellow foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-19986c6ce60e407290a13c37251c2fdb |
| Source note | uspto-grants-2012_10 |