反应详情

The reaction was carried out similarly as described in the preparation of compound 116, using compound 422 (0.21 mmol) and but-3-yn-1-ol (0.21 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 30:70 to 100:0 as the eluent to afford the title compound as light yellow foam.

1. customThe crude product was purified by continuous gradient flash chromatography