HCID 58677657, compound → [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(5-ethynyl-2-methoxy-phenyl)-methanone

HRID 2067220Notes

Reaction equation

HRID 2067220 reaction equation
ClC1C=C(NC2C=CC(F)=CC=2F)C=CC=1C(C1C=C(C#C)C=CC=1C)=O.[Cl:28][C:29]1[CH:34]=[C:33]([NH:35][C:36]2[CH:41]=[CH:40][C:39]([F:42])=[CH:38][C:37]=2[F:43])[CH:32]=[CH:31][C:30]=1[C:44]([C:46]1[CH:51]=[C:50]([C:52]#[C:53][Si](C)(C)C)[CH:49]=[CH:48][C:47]=1[O:58][CH3:59])=[O:45]>>[Cl:28][C:29]1[CH:34]=[C:33]([NH:35][C:36]2[CH:41]=[CH:40][C:39]([F:42])=[CH:38][C:37]=2[F:43])[CH:32]=[CH:31][C:30]=1[C:44]([C:46]1[CH:51]=[C:50]([C:52]#[CH:53])[CH:49]=[CH:48][C:47]=1[O:58][CH3:59])=[O:45]

Participants

3

Reactant 2

HCID 58677657HCID 58677657, compoundHCID 68421800HCID 68421800, compound

Product 1

HCID 86605526[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(5-ethynyl-2-methoxy-phenyl)-methanone

Procedure

The reaction was carried out similarly as described in the preparation of compound 407, using compound 426 (0.44 mmol). The crude product was used directly in the next reaction without any further purification.

Sources & evidence

ORD record
ord-e8907bfedf814000843bcb0063866655
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

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